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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG2 All Species: 23.33
Human Site: Y733 Identified Species: 46.67
UniProt: P16885 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16885 NP_002652.2 1265 147870 Y733 Y R K M R L R Y P V T P E L L
Chimpanzee Pan troglodytes XP_001147944 1265 147906 Y733 Y R K M R L R Y P V T P E L L
Rhesus Macaque Macaca mulatta XP_001111677 1265 147898 Y733 Y R K M R L R Y P V T P E L L
Dog Lupus familis XP_546812 1252 146274 Y733 Y R K M R L R Y P V T P E L L
Cat Felis silvestris
Mouse Mus musculus Q8CIH5 1265 147573 Y733 Y R K M R L R Y P V T P E L L
Rat Rattus norvegicus P24135 1265 147716 Y733 Y R K M R L R Y P V T P E L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508105 991 115582 T472 E L L E R Y N T E R D I N S L
Chicken Gallus gallus Q2VRL0 637 72514 K118 T A L E V I L K Y E P I D E V
Frog Xenopus laevis Q32NH8 758 87399 E239 Q Q G Q L E E E N T E E I A M
Zebra Danio Brachydanio rerio A5D6R3 784 89362 L265 D Q G E D A S L V H A K S L I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624101 1134 132613 L615 I P T D G A F L V R P S E K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 S421 K D D P I Y G S G G I Y M D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98 94.4 N.A. 94.1 94.7 N.A. 62.7 20.7 22.1 21.2 N.A. N.A. 40.9 N.A. 32.9
Protein Similarity: 100 99.9 99.2 97 N.A. 97.1 97.3 N.A. 67.8 33.2 37.5 34.9 N.A. N.A. 59.1 N.A. 49
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 13.3 0 0 6.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 20 13.3 20 N.A. N.A. 6.6 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 17 0 0 0 0 9 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 9 9 9 0 0 0 0 0 9 0 9 9 0 % D
% Glu: 9 0 0 25 0 9 9 9 9 9 9 9 59 9 9 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 17 0 9 0 9 0 9 9 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 9 0 0 0 9 9 0 0 0 0 9 17 9 0 9 % I
% Lys: 9 0 50 0 0 0 0 9 0 0 0 9 0 9 0 % K
% Leu: 0 9 17 0 9 50 9 17 0 0 0 0 0 59 59 % L
% Met: 0 0 0 50 0 0 0 0 0 0 0 0 9 0 9 % M
% Asn: 0 0 0 0 0 0 9 0 9 0 0 0 9 0 0 % N
% Pro: 0 9 0 9 0 0 0 0 50 0 17 50 0 0 9 % P
% Gln: 9 17 0 9 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 50 0 0 59 0 50 0 0 17 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 9 9 0 0 0 9 9 9 0 % S
% Thr: 9 0 9 0 0 0 0 9 0 9 50 0 0 0 0 % T
% Val: 0 0 0 0 9 0 0 0 17 50 0 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 50 0 0 0 0 17 0 50 9 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _